El Escorial Revisited:
Revised Criteria for the Diagnosis of Amyotrophic Lateral Sclerosis

A Consensus Conference held at Airlie House, Warrenton, Virginia April 2-4, 1998

Benjamin Rix Brooks, M.D.

Conference Organizer for WFN Research Committee on Motor Neuron Diseases

Robert G. Miller, M.D.

Chairman, WFN ALS Clinical Trials Consortium

Michael Swash, M.D.

Chairman, WFN Research Committee on Motor Neuron Diseases

Theodore L. Munsat, M.D.

Chairman, WFN Research Committees

Airlie House "Current Issues in ALS Therapeutic Trials'" Workshop Contributors

Contents:

• Introduction
• Revised Criteria for the Diagnosis of ALS
• Appendix 1 ALS-Plus and ALS-Mimic Syndromes
• Appendix 2 ALS with Laboratory Abnormalities of Uncertain Significance (ALS-LAUS) Syndromes
• Appendix 3 Employing Electrophysiological Studies
• Appendix 4 Employing Neuroimaging Studies
• Appendix 5 Employing Clinical Laboratory Studies
• Appendix 6 Employing Neuropathology Studies

Tables and Figures:

• Schema of El Escorial Revisted (large image)
• Table 1 - Lower Motor Neuron and Upper Motor Neuron Signs in Four CNS Regions
• Table 2 - Glossary

Correspondence:
Benjamin Rix Brooks M.D.
ALS Clinical Research Center
Neurology Department
University of Wisconsin Hospital & Clinics
Clinical Science Center H6-563
600 Highland Avenue
Madison, Wisconsin 53792-5132 USA
Telephone: 608-263-9057
Fax: 608-263-0412
Email: brooks@neurology.wisc.edu