Definite

tress regions with both UMN and LMN abnormalities specific clinical and exclusionary criteria met; no other diagnosis possible on basis of clinical distribution or laboratory findings

 

Dementia

progressive deterioration of specific cognitive functions

 

Extrapyramidal

clinical features localizable to basal ganglia and/or midline cerebellum

 

Hyperreflexia

spread of deep tendon reflex outside stimulated territory

 

Minor

subjective and objective complaints confirmed by examination (utilization of instrumental sensory testing may increase the detection of sensory abnormalities)

 

Onset

time of first subjective symptom noticed by patient which later is confirmed by examination

 

Possible

specific clinical and exclusionary criteria met; UMN and LMN signs in one region; or UMN signs in 2 regions

 

Probable

specific clinical and exclusionary criteria met; UMN and LMN signs in 2 regions (UMN signs rostral to LMN signs)

 

Radicular

distribution conforming to particular nerve root

 

Region

brainstem, cervical, thoracic or lumbosacral spinal cord levels (regional involvement is defined by either right or left sided signs)

 

Required

necessary or sufficient

 

Segment

single brainstem or spinal cord level

 

Spread

involvement of new anatomic segments or regions in the central nervous system

 

Support

neither necessary nor sufficient, but may suggest

 

Systemic

non-central nervous system

 

Weakness

decreased isometric strength

 

Worsening

increased weakness of muscles in previously affected segment

 

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